Piling up the JNK: Drug synergy through ER stress

Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid

BACKGROUND Gambogic acid (GA) was extracted from the dried yellow resin of gamboge (Garcinia hanburyi) which is traditionally used as a coloring material for painting and cloth dying. Gamboge has been also used as a folk medicine for an internal purgative and externally infected wound. We focused on the mechanisms of apoptosis induction by GA through the unfold protein response (ER stress) in H...

ER stress and the JNK pathway in insulin resistance

*Correspondence: Hideaki Kaneto, MD, PhD, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; Tel. (81-6) 6879-3633; Fax (81-6) 6879-3639; e-mail: [email protected]

P42: Luteolin Counteracts ER Stress in PC12 Cells through Moderating ER Chaperones and Heat Shock Proteins

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Piling Up, or Floating Away

ER stress PERKs up an miRNA

ER stress PERKs up an miRNA B yrd et al. describe how a microRNA (miRNA) fi ne-tunes a cell's response to ER stress. When stressful conditions disrupt the ER's normal function, the cell activates an unfolded protein response (UPR) that restores the organelle's ability to fold and export proteins to the secretory pathway. The transcription factor XBP1 is a key component of the UPR that boosts ER...